I haven't played the Witcher in a long time, but there doesn't seem to be much of a difference except for the Witcher's invisible magical imps who immediately carry away anything you drop on the floor. That's not a good thing, that's just annoying and dumb.
If you want to play a game where anything you drop is gone for good, there's nothing in Skyrim that's stopping you from playing that way. No one is forcing you go carry every bit of loot back and store or sell it.
But just because you like that style doesn't mean everyone does or that it's even the best style. Especially with the literally crazy idea to have random items fall out of "holes" in the player's inventory. How in the world would that be fun in any way?
There are two schools of thought for inventory management:
Divine Divinity had a system where you had a carrying capacity - too much and you're reduced to walking, reach your limit and you can't move at all.
Diablo 2 had a grid-based inventory - each item took up a different amount of slots in the inventory.
Divinity 2 had a strange hybrid: each item took up one slot, but you had a limited capacity of slots. 100 books and 100 cuirasses took up the same amount of inventory space.
Of these choices, I prefer the strenght-based carrying capacity method of limiting inventory space.
