I saw someone had mentioned unarmed already, but its something that I really am a fan of. Pretty much fell in love with RPG's with Icewind Dale 2 (and the monk class).

Depending on the level of effort you are interested in putting into the weapons/damage mechanics, you could create "hand weapons" for monk-like classes (quills, oils, needles, etc.) that would modify the way a monk-like class fights, making them a kind of jack of all trades depending on equipment.