I DD there is 1 skill you can invest in to regenerate Health: Survivor's Instinct .
I like to see in D:OS such a skill as Survivor's Instinct OR finding (via quest or quest reward) a piece of equipment that let regerate you mana and/or health ... or something else, like a perk or a "special item".
Or: a skill like Life Leech or Mana Leech ? Stealing mana of health points from an enemy ?
I like the idea of NO regeneration of MP or HP for D:OS !