TBH, when I was playing DKS, my health regenerates faster than my enemies damage me even on last boss fights. Of course, this does put into equation my equipments. Health regeneration generally destroys the challenge in the game.
A possible exploit that is present on 500k stretch goal mechanic is the "in/out" of battle to/from homestead. You can jug a lot of potions while in your home, so it's possible to exploit it during a boss fight. Unless there Larian implements a good control measure for this, it's going to be exploited much.
