I have a 24" 1920x1080 monitor next to a 19" 1280x1024 one. It'd be amazing if I could have the inventory, map, quest log, etc on the smaller one while the main game screen, uncluttered with UI elements, is on the larger one. Using it for local mulitplayer as suggested directly above would be another fantastic idea. At least leave it open so it isn't so hard to mod in.
