I went into it like so:
2 v 2 easy, medium, hard, insane, then 1 v 1 easy, medium, hard. My first loss was at the 1 v 1 insane, because insane AI blatantly cheats :p. No human players yet, due to, uh... personal issues. Also, the game's been updated several times since I started... yesterday. No idea how they changed the AI, if at all.
But I guess if one easily grasps the way an RTS plays, they'll have little trouble adapting to the game. If they're not familiar or confident with RTS game play... I can't say :s.
I would suggest to try to tackle the AI from easy to difficult and stop and practice at the level that you fail.
Hope this helps someone in their tackle of the game.