Personally I hate respawns. I don't mind games that include them to a limited degree (e.g. Morrowind), but on the whole I prefer dead enemies to stay dead. I'm playing Planescape: Torment at the moment, and the endless respawning bandits in the Hive are driving me crazy - as is the fact that if I enter a dungeon and kill some enemies, then retreat to rest and heal, all of them are back the moment I re-enter. At least give us a grace period of a day or two before the respawns!
As for D:OS, my guess is that it'll be similar to Divine Divinity, which didn't have respawns. But you never know.