Could always have an Ultima style respawn where enemies pop back the second they go off frame. Was great for farming experience, but not so much for exploring, haha.
But I like no repawns personally because it feels like you are having an impact on the world for good or bad. I remember getting bored of Elder Scrolls Oblivion and decided to do a pure evil playthrough and kill everyone in every town in Cyrodill, almost worked too until I visited a town I previously wiped out and everyone was running around all willy nilly like nothing had ever happened.
Now true, you never want to see your favorite townsfolk die and never come back, but hey, that what that reload buttons for.

reload button.