Could you try the solution where you disabled one of the graphics adapters, but first remove all files under ..\Documents\Larian Studios\Dragon Commander

this will reset all gfx settings to default before you try launching the game

the problem is most likely caused by the double adapters

could you send a report.zip (or dxdiag.txt if that fails) made at the time when only one adapter is active?
to supportdc@larian.com with a link to this topic