No, AFAIK there isn't a way to one click and attack until an opponent is dead, and no way to use spells in the middle of a jump.

For your mage, Magic Missile has a 1 second cooldown time and is quite effective. In DKS / D2:DC the magic damage bonus from equipment is added to spells (including each missile in a volley of Magic Missile), so it is best to duel wield weapons with the largest magic damage bonuses and enchantments available (no need for the dual wield skill, as the off-hand penalty doesn't apply to magic).

There are no weapons for unarmed combat, but you can still do decent damage: Monk/Ninja Build.