There is one possibly game breaking issue. NPCs seem to find reasons to dislike you at random, and when Mayor Cecil deemed me unworthy of his favour, I was unable to speak with him (much less walk by his house!) without being attacked. When I did finally engage him in conversation, I was unable to offer him a gift in return for disposition increase. The conversation would end, and he then proceeded to attack me again. This happens with all other NPCs of similar disposition.
I have noticed this as well. The Duke of Ferol has taken an immense disliking to Scarlett (who has never spoken to him, much less attacked him) and won't even talk to her. Thankfully Roderick can still have conversations with him so I can proceed with the quest, but I've had this problem with other NPCs too.
