Boris and Steven are remarkably resilient for deathly sick men! I tried poisoning them, shooting them with fireballs, freezing them, sending boulders smashing into them, and it didn't hurt them a bit! (I was trying to see if I could break the dialogue/decision by killing one of them).
On the other hand, Cynthia's door on the other hand, while resilient, will eventually break under a determined assault, then you can walk in and take the teleporter pyramid and have a conversation referring to Zixzax giving you a teleporter pyramid, which he has not done at that point. Attempting to use your wrongfully acquired pyramid does nothing until you get the other one from Zixzax, though.
Kein - as far as I know, 1.0.47 is the same as 1.0.45 except they added music.