Windows 7 x64; i7-3770 @3.4Ghz; 8GB RAM; NVIDIA GeForce GT 630
D:OS video settings auto detect - Ultra

D:OS takes ages to load or to start a new game.
All the mouse clicks register with delay or some time not at all. This happens for left/right click and on all objects like (but not limited to):

-Chests and barrels (open, pickup items, close)
-Doors
-Pickup items
-NPCs (to talk to them)
-Dialog (selecting choices)
-Inventory items (for example I right clicked on the pyramid many times with no luck and when I started to loose hope it finally worked)
-Game menus and dialog boxes (like Save/Load/Accept)
-The x buttons to close inventory/map/etc windows
...

and so on. The response to virtually every click is delayed or even missed in some cases.

This isn't happening in any other game (like Titan Quest, Grim Dawn, Torchlight II).