In "tecnical issue" there are a lot of posts like mine and i have just sent some emails to the divinity support. I hope in a solution quickly...

Originally Posted by Kein
[quote]
Let's start from the beginning: what is your OS? WinXP? Vista? Seven? 8? 32bit or 64 bit? Do you have any AV software?

Also, can you try to run the game manually, from:
X:\...\Steam\SteamApps\common\Divinity - Original Sin\Shipping\
via EoCApp.exe with administrator rights?

To do so, right click on EoCApp.exe, select "Run as administrator". See if you cansave the game. Try to use both methods: menu and quicksave.