Indeed, this is not exactly what I had in mind, but it is easy to imagine that someone who is very good at two handed weapons would pay special attentions (in a kind of a "professionnal" way) to two handed weapons he/she comes by in the world, and so find/loot them more often.
But then, NO RANDOM two handed sword if the enemy you were fighting did not use one...
Another example. Sometimes, I find teeth in the world. Why the hell would any sane PC be interested in teeth ? But, as a crafter/alchemist/jeweller/whatever, you might know a recipe that requires some teeth, and so pay more attention to suitable teeth for your recipe, and so start to loot them on corpse, or "loot" them more often.
It doesn't sound TOO hard to implement (although things are rarely so simple).
A proper loot table, taking into account all skills as variables, the looted item/critter, and so on, could be a real challenge to create.
IMHO, loots are a great way to increase the feeling of growing capacities and skills for a PC, but it would requires a lot of fine tuning, dedicated gathering/looting skills (for the PC, not the devs ^^), and so on, to be really interesting. But that would be another game.
Inadequate/unrealistic loot tables are a design flaw IMHO.
