So, is anyone else unable to talk to Charlene? I vaguely remember someone posting about this bug before, wondering if it's permanent.
She was 'fixable' in the previous build by using a NPC party member to talk to her, which triggered the generic "I will only speak to the real source hunters" rebuff, which then reset her dialogue script.
Try that (note: I'm waiting for the next build + content before testing more).