I like printed manuals ... but I never really read them.  To be honest I generally look at them for the artwork.  I generally expect the game to give me enough information to play the game 'in game'.  Also later patches can make many parts of printed manuals inaccurate, and thus useless.
Maybe a little side-demo shipped with the game that a first time player can use to figure out the workings of the game.  A five minute tutorial like this beats the heck out of a huge paper manual.  After you've done the demo once, just go straight into 'New Game' from then on out.