5.) Combat targeting is really hard in a lot of circumstances with items in the foreground or clumped up enemies. It seems to require too much precision. Occasionally I end up walking around enemies instead of attacking them.
Have you tried rotating the view and/or zooming in after panning the view over to your target?
Yes that does work somewhat, but i understand completely what he is saying.
Even in a "let's play" video i checked recently people were complaining about it, it's not easy to target atm, you need to be "dead-on-top" of the target nearly to a pixel precision and sometimes you need to micro-slowly-move your mouse to target stuff. Moving your camera it's a workaround sure.