Just picked up the game last night. Like what I see so far.
Luckily, only ran into one bug thus far:
-Floating barrels. Happens ~60% of the time after throwing one and then walking away until it's off-screen. I can still grab it.
I've been playing Diablo 3 lately, so maybe it's just me, but the characters feel very slow while walking/running around. Not sure if this counts as a bug.
S'more:
-As others have mentioned, sound cuts in and out, and eventually dies down completely--with the exception of fireplaces and portals.
-Target box is small.
-C'mon, Murphy. You're supposed to run into hazards to save people, not because you're trying to tell me Timmy fell down a well while I'm in the middle of a fight.
-After playing for a few hours, start to hear static around portals and fireplaces.
-Game crashed once while quitting game. I've only played for about 10 hours, so a lot more crashes might pop up.