I also been encountering this problem,

When I teleported an enemy on a broken barrel, the enemy was untargetable.

Wolf standing on the corpse of another wolf made the one still alive untargetable.

When you click on an enemy (or you think you do anyways) but you hit that one pixel between the space of his legs because he moves a little bit in animation, it will click the ground instead and make you walk and lose combat points for your attack, a bit bigger hitbox would be nice.