One really strange I issue after starting up a new game on the beta.
The audio in the intro cutscene cuts in and out a lot. The dialogue just cuts in and out. Its in different places every time, so not sure if its a computer loading issue or something. Quick video to display issue (only does it once on the first sailors dialgoue as opposed to other places I've heard before): http://youtu.be/zRq9ANFRf9o
Can't say I noticed it very much in general ambient audio after the cutscene like some others have mentioned though.