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In the King's Crab inn, second floor.
The party includes Madora.

Spoke to Shereth, talked about how her services are dangerously close to sourcery, but I/we let her carry on.
Didn't see any exclamation mark above Madora's head after this.

Then went and talked to Eglandaer (the old Elf), conversation triggered a fight, killed him. Saved and quit right after that.
Next day, I load the save and there's an exclamation mark above Madora's head, but I can't talk to her - now I can't talk to any NPC, in fact.

Tried to reload the save several times, didn't help.