Let us for example start with just one talent and get one talent point every 5 levels. So, we can maybe get just 5 talents in total and the choice suddenly starts to really matter.
That may be a little too harsh. That would certainly make my Rogue pretty crappy if I had to wait until Level 5 to have both Speedcreeper and Guerrilla.
A few other thoughts on particular talents:
The zombie talent is a very cool and useful one. However, it does not really have any downsides. The zombie character can heal infinitely while standing in a poison pool, the scarce supply of healing potions and food can now be divided between other party members. And the most important point: the undead mages usually cast poison darts and not healing spells - thus they can not really harm the zombie character.
Uh, I think Zombie has a major downside in that you require poison pools everywhere to heal. That may be great for certain situations, but terrible in others, like fighting fire-based enemies. Plus, I assume there will be a lot fewer undead enemies after Act 1. (If there are loads of undead still, then poison damage will be pretty terrible.)
What does the packmule talent do? Does it just increase the weight of items you can carry? If this is so, then it is pretty useless. I pick up the items only with my very weak witch (strength 5) and have not run into any difficulties with weight limit yet. If this should happen, I still have a few other characters for additional inventory space. You can also store items in your shelter plane and so on...
Yeah, my only issues with carrying things are that there's no sort button yet.