Thanks for trying, but I don't think that's necessary. The problem with Desdemona, Madora and not being able to talk to other NPCs is known (and I think should be fixed in the next update). I don't recall seeing Fenix66d's issue before, though (male characters being able to talk to NPCs and female ones not), so thought it wouldn't hurt to send a save of that to support (don't know if that variation would have been obvious when they fixed the main issue, though it is probably irrelevant).
Just a follow-up to my original posts. I started a new playthrough and reached this quest again. As noted the problem with Desdemona and Madora was encountered again. I teleported to the Cyseal North Rift Gate, went to the market square area and tried to interact with the Potion Vendor (others too). Again Scarlett was unable to interact with any NPC in the city but this time neither could Roderick. Only Jahan was able to interact with any NPC vendor.
Read in another thread that exiting via the East Gate and then re-entering the city will fix talking issue with vendors. Tried this and it did indeed work, except for Madora which is a known issue and results in the Lost Love at the Lighthouse quest from being completed..
