I've only just started trying Lone Wolf out now, so I can't offer any conclusions or insights. I tried a Battlemage/Ranger combo and got them to level 3 before I decided that I really needed a lot more Ability points, even to just give minimal abilities to the Battlemage. So I started over with that guy as a lone wolf. It hasn't been too much harder, but he also hasn't been so incredibly super-durable either.