I would say the easiest solution is the following:
Adjust the loading time for quickload to about 5 - 10 minutes, so no one will ever be tempted anymore to use save-scumming for better loot -> problem solved.
(P.S My good old 5-year-old laptop actually has something like 7 minutes loading time for a savegame so I am not even dreaming about abusing this feature^^... So, I am speaking out of experience here^^...)