Player inventory doesn't make any sense
Well, feel free to make a mod that eliminates the player's inventory. I'm sure there are a couple people somewhere just waiting for realistic size and weight limits in RPGs, because being able to carry loot just doesn't make sense.
In a "make sense" system and coherent world, it is not a problem.
So if people ignore the message box that comes up pointing out how they can trade with NPCs, how much extra hand holding is required?