Good question. Also good question : will Original Sin be at E3? I know it has been before.
If they can actually get any exposure there sure....but I never saw any news come out about Original Sin at E3 or Larian and the whole show was stolen by Sony with Microsoft spectacularly shooting themselves in the foot and pretty much everything else was drowned.
Beyond that I view E3 as mostly being for and about consoles, granted most games there do release on PC too but the demo stations are consoles and you have the big console manufacturers leading the press conferences before the big publishers have theirs so that puts a small independent company like Larian who wants to show a PC only game in a very awkward spot even if everyone should take their eyes off whatever they're looking at and take notice of one of the very few best games at the whole show.