Honestly, whatever is easier for the developer is what I would prefer - if having a fixed seed is more difficult than I say leave it as it is. Ultimately it is up to the player to decide how they want to play the game and if it is fun for someone to save/reload 5 times to get something they like than they should be able to. If you prefer not to than you don't have to - just accept the loot that you find/is dropped the first time around. I recall reading that you can save mid combat and re-kill bosses to get better drops - that I think should be discouraged by not allowing saves during combat so as to force the player to re-play a boss fight to use this exploit (apologies if this has already been done - I never saved in combat).
Finding loot is a fun part of the game and in the past I know I've exploited similar "features" in games (Master of Magic - re-killing high level nodes for books/retorts/good artifacts, anyone?), but not something I do anymore, partly from playing roguelikes and learning to enjoy adapting your play style to what you are given.
Either way, I don't think this should be forced on the player, and if someone complains that if it is there it is tempting to use the exploit, then it is on them to control themselves
. I personally am looking forward to an Ironman mode where tensions actually run high. I played through the beta and had great fun (normal, 2 char with Lone Wolf) but knowing you can always re-load allows you to make stupid mistakes, not to mention never use scrolls/potions (never once used a scroll of potion of resist/+stat). Maybe I've been playing too much ADOM
