I don't know if it's been reported already, sorry if it has
I thought I'd give it a try on my dev machine today, it's a rMBP 15" Late 13 with the nVidia, 16GB RAM and running OS X 10.10 (Yosemite) DP1
The game doesn't start, it pops up a message saying "Video System Failure"
I've attached a screenshot, and no, I haven't created any spaces.