In another topic (
Saving the game doesn't work) someone reported that re-installing their graphics drivers fixed the problem. Support suggested that, but I don't know if that is a known issue, or that particular dxdiag report, or something, indicated a problem with drivers.
Updating the driver does not fix this issue. I believe it has something to do with the memory. The new save system has "Freeing space for save" and "Clean up level" stages. Every time I see these, the save is good. Otherwise, the save crashes.