I am experiencing the exact same issue as the OP. Game crashes as soon as I reach weight limit, and try to move. GPU drivers are up to date, also tried running in XPSP3/win 98 compatibility mode to no avail. If it helps:
i7 4770k stock speed, 16GB corsair 1866, GTX660 SLI, sabertooth z87 mobo. nothing OCd,
I'm using the steam version of the game (1.5 if I recall correctly)