I actually have a very similar issue too but only on my work PC (I'm tyring to play D:OS in my lunch hour smile No problem at all with the game at home but every time I launch it from work, create profile and then restart game, profile is gone.

I'm in the process of completely removing the game install and reinstalling from Steam to see if that helps.

No idea if my issues is in any way similar to yours but I guess it's something about the Steam cloud save thing again?
I also saw the suggestion about using Dropbox on another thread but this does not help either. It's weird, because after using the mklink /D commmand I can see my profile being updated on Dropbox but again, as soon as I restart profile is gone?

Thanks for any help smile
Russ