Hey,;
1. maybe you can place a little weight on the ALT-button so it stays "on" ;-)
(sometimes I do this with the CTRL-button while selecting different cells in a Excel file )
3. Not any experiences of bad or good combinations (so far), but reading the Game Manual I read that it : is a good idea to build a party that covers many talents . ..... a good idea especially recommended for first-time players . ;-)
Good luck and have fun !