Glass Cannon is totally worth it, and so is Lone Wolf. But there is a catch. You Essentially can only truly pull it off IF you have 100% resist in most if not ALL elements, which in turn lets you heal and essential be immune to well elemental damage.

Generally speaking get all 100%+ resist in everything is hard till the last 1/3 of the game where you can "farm" and reload multiple times at vendors for elemental essences to use on your gear.

Basically Hybrid builds seems to dominate if you can get a hefty stack of essences to slap on +2 +2 +2/+1 yellow gear.

This is all assuming you can get the cash (I stole a ton of paintings and gold cups, and bartered well), and of course the essence drops and vendors.

(SPOILER) You can later buy a bunch of essences from your homestead.