Stupid question, but is it possible to purposely gimp resistances on your warrior for more of a challenge?

It would appear to me that in a late game situation, your characters should be fairly powerful, kick ass and take names? Is this an issue with the resist system itself or a matter of personal character design choices (game play) made by the user?

A good analogy maybe (if you know the Gothic reference), the game plays like vanilla Gothic 2, and some users hoped it played more like NOTR (more difficult and unforgiving).