All mine are hybrid and I had no problems. Except first time I faced B-Rex when I was like 2 levels under him and did not realise would spawn those elemental's. I also had problem I guess first few times took on skeleton general and his sister I think it was...again problem I was 2-3 levels below them at the time but I figured a trick to take them down by funneling them through gate at bottom of the stairs one by one. Other than those all my characters were hybrid and did fine so go for it I say.