I have a ranger/rogue, and correct in act 1 his backstabs are more or less like the twohanded attack. But am now level 10 in act 2, and the rogues damage has surpassed the twohander in damage. So it gets stronger faster and will become high(est) damage.

I usually use ricochet or barrage as I move towards the fight. Then go rogue. I like that I can jump out to safety if need be and switch to bow and plink away while I heal. The special arrows I use situationally and they are a good asset to have.