Larian Studios Forums Divinity - Original Sin Divinity - Original Sin - Technical Issues Cannot 'Continue' or 'Load' game.

I've had the same problem once, I suspect it was due to Steam "synchronizing" (in that case deleting my saves).
That was around the time Larian disabled the Steam-cloud feature.
My saves contained only empty folders after it happened, luckily I had only just arrived in Cyseal anyway.