Please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the D:OS support tool (for the PC version). The report will contain system and game information, any crash dumps, and your saved games (which are not relevant in this case, so if file size is an issue they can be deleted from the zip).


If you didn't do so already, try browsing to the '..\Documents\Larian Studios' folder and renaming the 'Divinity Original Sin' subfolder.
This folder contains the saved games, configuration files and a level cache folder. Deleting or renaming it will get the game to recreate it on startup; playing the game from a different Windows user account would effectively do the same thing.
If that gets the game to load, you can move your save folders from the renamed folder to the newly created profile.