You could try creating a new user in Windows with a default location My Documents folder, and then right click the game executable and run as that user...
Please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the
D:OS support tool (for the PC version). The report should contain system and game information, any crash dumps, and your saved games. I'm not sure if lack of a saved profile will cause a problem with the support tool.
