Here is an updated link for a 1.0.219 replacement
Divinity Original Sin folder (695KB), if you want to try extracting it into your '..\Documents\Larian Studios' folder, and see if that makes a difference (it may help if the problem is in setting up the initial My Documents folder and configuration files).
The graphicSettings.lsx file is set to a 1152x648 resolution, and windowed mode (instructions for changing this in the spoiler). If this lets you start the game, you can change the resolution (and quality settings) in the Video options.
You can edit the graphicSettings.lsx file (in the '..\Documents\Larian Studios\Divinity Original Sin' folder) in Wordpad, or other text editor, to manually change the resolution. Search for the section:
</node>
<node id="ConfigEntry">
<attribute id="MapKey" value="ScreenHeight" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1600" type="4" />
</node>
<node id="ConfigEntry">
<attribute id="MapKey" value="ScreenWidth" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="2560" type="4" />
</node>
Search for 'fake' near the start of the file to set the display mode (if both FakeFullscreen and Fullscreen are set to zero, it will be in Window mode).
<node id="ConfigEntry">
<attribute id="MapKey" value="FakeFullscreenEnabled" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="0" type="4" />
</node>
<node id="ConfigEntry">
<attribute id="MapKey" value="FrameCapFPS" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="60" type="4" />
</node>
<node id="ConfigEntry">
<attribute id="MapKey" value="Fullscreen" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1" type="4" />
</node>
Here is a link for a
1.0.252 save (2.9MB). In cases where D:OS will start but there is a problem starting a new game, it may be useful to try an existing save.
Old links:
EDIT:
Enhanced EditionThe EE is a less likely to have a problem creating the initial My Documents files and folders. Regardless, here is a replacement
D:OS EE folder, which you can try downloading and extracting into your '..\Documents\Larian Studios' folder, after renaming/deleting the existing 'Divinity Original Sin Enhanced Edition' subfolder.
The graphicSettings.lsx file is set to 1280x720 Windowed mode, Very Low quality preset, which you can change in the options (manually, or hit autodetect) if this gets the game to start.
If that doesn't help, delete the downloaded My Documents D:OS folder and try starting the game again.