Speaking of games like BG2 (or at least NWN1 and 2) - in those titles, lockpicking was a viable alternative to simply bashing/fireballing a container because fragile items within the container (like potions) would break if you used force to open the container. It was simple, logical, and good for gameplay balance. Of course, this wouldn't help with doors, but just a thought.
Either way, as it is, lockpicking is pretty much a junk skill in D:OS.