Having finished the game, I can only think of 2 occasions where Lockpicking was was semi useful:
1) Entering Loic's Cellar right after you enter visit Silverglen. Since you can find 2 Bloodstones there, you are able to unlock the demon that allows you to respec / trade talents for ability points in addition to the forge (which is just more comfortable than using the one in Cyseal).

2) Getting to the hidden servants a bit earlier, although you would have been able to get there very shortly afterwards anyway and those who replay the game already know the spot.

Has there been any other occasion, where Lockpicking did something relevant for you?

Last edited by eidolon; 15/07/14 10:24 AM.