Or you could go back to an earlier save and lose minutes of game play
Yeah, because you'll realize how OP is leech immediatly after choosing it... It takes a lot of time, and at the beggining game is very hard anyway. But if you pick a couple of talents like leech + comeback kid, on second map you suddenly realize you're immortal. And this is wrong.
or simply don't cast bloodletting on your character with leech lol.
Sure, people also could play naked, don't use any armor. Or try to kill enemies with their bare hands. But this applies to people who like to replay the game. On your first playthrough, when you're more casual type of player, you just want balanced difficulty, a challenge, without making this harder for yourself on purpose - because it's destroying immersion. If some talent/skill or their combination make you immortal even on hard difficulty - It should be nerfed. You want immortality, use cheats. Eot.