If you start a new game, can you save and load?
Please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the
D:OS support tool (for the PC version). The report will contain system and game information, any crash dumps, and your saved games. If file size is an issue, any saves not related to the problem can be deleted (so keep your most recent working save, and then several from after the update).