"Is the game particularly balanced toward any particular combination?"
1h strength weapons are relatively bad compared to the 2h ones and Lockpicking/ Pickpocket are not worth putting points into them.
A crafted and boosted weapon (like sharpened on a whetstone) has about the damage output than an unbuffed magic one that is 4 level higher once you get blacksmithing+crafting to lvl 5.

Last edited by eidolon; 21/07/14 07:36 AM.