1) Hitboxes. I hate having to reload a fight because an enemy fidgeted and instead of attacking them my archer ran headlong into five enemies because I clicked the wrong spot. Some enemies are more prone to this than others, but it's possible with all of them. It's also a thing when a lot of enemies are grouped closely together since you might not target who you want to, or be able to target someone at all. Also related to this is that some enemies have difficult or oddly-shaped hitboxes, like the spiders in the desert north of Luculla. This can make them difficult to target all the time, not just when they move. Small things are also difficult to find (switches) or click on (rats) at times because of their tiny highlight boxes.
You can click on the squares at the top of the screen instead of the hit box itself.