Saving Issue:

It seems a few are having a saving issue, I am not totally sure of the circumstances but the mod doesn't actually change anything related to the code, so this maybe an issue with the game itself.

Is it because players 3 and 4 are triggering story elements? Is it because you are on online-multiplayer? Try to recreate a log of details which led to the point where it simply stops.

If you also played roguelikes version, is the same issue happening in his?