i have the same problem
Windows 7 Home Premium 64-bit (fully updated)
INTEL Core i7 CPU 920
560 GB RAM
AMD RADEON HD5800
i disable all background processes, reinstalled video drivers, reinstalled directx
i check the windows log but didn't find anything usefull
i tried in window mode
i tried in false full screen mode
i tried in many resolutions mode and in different frequency
i already send information to larian team
i tried also to manipulate all the video options, disabling them one by one
At this moment, is not possible to play this game